Jacalin Has Chemopreventive Effects on Colon Cancer Development

Figure 1

Treatment protocol. Mice received 4 successive intrarectal deposits of 0.1 ml of PBS or MNNG solution (5 mg/ml) twice a week for 2 weeks. Starting 2 weeks before carcinogen administration, animals were treated orally (0.1 ml/mouse) with PBS () or jacalin (0.5 and 25 μg) () three times a week for 10 weeks. After 10 weeks of treatment, mice were euthanized, and the colons were removed, fixed, and processed for histological and immunohistochemical analysis.