Jacalin Has Chemopreventive Effects on Colon Cancer Development

Figure 4

Downregulation of COX-2 expression in colonic tissue of jacalin-treated mice. (a) Cyclooxygenase-2 expression was evaluated using anti-COX-2 antibody. Morphometric analysis showed decreased COX-2 expression in both MNNG-exposed and unexposed animals treated with the higher dose of jacalin. (b) Representative immunohistochemistry images of COX-2 positive cells in the intercrypt spaces of the control group; (c) MNNG-exposed group; (d) MNNG-unexposed group treated with jacalin 25 μg; and (e) MNNG-exposed group treated with jacalin 25 μg. COX-2 index was calculated as the number of stained cells in the intercrypt spaces and is expressed as mean ± SEM for each group. Statistical analysis: one-way ANOVA (Kruskal-Wallis) and Dunn’s multiple comparison post hoc tests. to control group. to PBS group. ; . Arrows show COX-2-positive cells.

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