Bisphenol A Is More Potent than Phthalate Metabolites in Reducing Pancreatic β-Cell Function

Figure 6

No effect of environmentally relevant BPA concentrations on insulin secretion after concomitant exposure with glucose. INS-1E cells were incubated for 1 h with glucose-free KRBH buffer, followed by 2 h incubation with BPA or the positive controls IBMX (25 μM) and Forskolin (0.25 μM) in the presence of 6.7 or 16.7 mM glucose in KRBH buffer. indicates significant increase compared to control (2-way ANOVA, repeated measures, with Bonferroni posttest, ).