A Simple Model for Inducing Optimal Increase of SDF-1 with Aminoglycoside Ototoxicity

Figure 3

The cochlear morphology in the mouse model of ototoxicity analyzed after furosemide and kanamycin treatments showed cochlear degeneration. (a) and (b) show the normal microstructures of cochlea, especially of the organ of Corti and the spinal ganglion. We compared the hematoxylin and eosin staining in the cryosections from (c) normal mice and mice treated with furosemide, (d) 130 mg/kg + kanamycin 420 mg/kg, (e) furosemide 130 mg/kg + kanamycin 550 mg/kg, and (f) furosemide 130 mg/kg + kanamycin 600 mg/kg. SV: scala vestibuli; SM: scala media; ST: scala tympani; RM: Reissner’s membrane; TM: tectorial membrane; BM: basilar membrane; SG: spiral ganglion; OHC: outer hair cells; IHC: inner hair cells. Scale bars: 20 μm.

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