A Simple Model for Inducing Optimal Increase of SDF-1 with Aminoglycoside Ototoxicity

Figure 4

Phalloidin-FITC immunofluorescence shows loss of outer hair cells. Immunofluorescence in sections from mice treated with (a) furosemide 130 mg/kg + kanamycin 420 mg/kg, (b) furosemide 130 mg/kg + kanamycin 550 mg/kg, and (c) furosemide 130 mg/kg + kanamycin 600 mg/kg. The outer hair cells in the three layers show dysmorphic, out of line cells and deletion of cells. (d) There were significant differences for counts of outer hair cells in the kanamycin 550 mg/kg and 600 mg/kg treated groups than in the sham control group.

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