Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer
Table 2
Baseline characteristics and clinical outcomes between conventional and cryptogenic stroke mechanisms.
Conventional ()
Cryptogenic ()
P value
Time delay to visit, h [IQR]
1
1
0.624
Age, y [SD]
69 ± 9
70 ± 9
0.899
Sex, male %
4 (67)
4 (67)
1.000
Hypertension, %
3 (50)
1 (17)
0.545
Diabetes, %
2 (33)
0 (0)
0.455
Hyperlipidemia, %
1 (17)
2 (33)
1.000
Current smoking, %
2 (33)
1 (17)
1.000
Alcohol, %
4 (67)
1 (17)
0.242
History of stroke, %
1 (17)
0 (0)
1.000
Venous thrombosis, %
0 (0)
2 (33)
0.455
Cancer type, %
0.688
Lung
2 (33)
3 (50)
Gastric
1 (17)
1 (17)
Colorectal
2 (33)
0 (0)
Hepatobiliary
0 (0)
2 (33)
Genitourinary
1 (17)
0 (0)
Systemic metastasis, %
1 (17)
5 (83)
0.080
Brain metastasis, %
0 (0)
3 (50)
0.182
Initial NIHSS [IQR]
13 [5–19]
10 [7–15]
0.935
SBP, mmHg [SD]
130 ± 27
151 ± 28
0.213
DBP, mmHg [SD]
77 ± 23
84 ± 12
0.479
Initial antithrombotics, %
0.476
Low-molecular weight heparin
1 (17)
4 (67)
Warfarin
1 (17)
0 (0)
Antiplatelet agent
4 (67)
0 (0)
No treatment
0 (0)
2 (33)
Intravenous alteplase dose, %
1.000
0.6 mg/kg
4 (67)
3 (50)
0.9 mg/kg
2 (33)
3 (50)
Initial DWI lesion
0.061
Single territory
6 (100)
2 (33)
Multiple territory
0 (0)
4 (67)
D-dimer, µg/mL [IQR]
1.30 [0.73–8.28]
4.51 [3.70–20.0]
0.109
CRP, mg/dL [IQR]
0.03 [0.03–0.11]
2.79 [0.38–12.20]
0.085
PT, INR [SD]
1.09 ± 0.05
1.15 ± 0.20
0.497
aPTT, sec [SD]
34.1 ± 4.6
31.5 ± 9.8
0.578
Hospital stay, day [IQR]
16 [9–28]
12 [6–17]
0.420
Discharge NIHSS [IQR]
4 [2–7]
28 [8–42]
0.063
Early neurological deterioration, %
1 (17)
3 (50)
0.545
Hemorrhagic transformation, %
2 (33)
5 (83)
0.242
In-hospital mortality, %
0 (0)
3 (50)
0.182
3m mRS, %
0.043
0
1 (17)
1 (17)
1
3 (50)
0 (0)
2
0 (0)
0 (0)
3
1 (17)
0 (0)
4
0 (0)
0 (0)
5
1 (17)
1 (17)
6
0 (0)
4 (67)
We used Student’s -test or Mann–Whitney U test for continuous variables, while chi-square test or Fisher’s exact test was used for categorical variables.
