Liver X Receptor Agonist TO901317 Attenuates Paraquat-Induced Acute Lung Injury through Inhibition of NF-κB and JNK/p38 MAPK Signal Pathways

Figure 7

Effects of T0901317 on the expression of Bax and Bcl-2 and apoptosis. The lung tissues were collected 72 h after PQ administration to determine the expression of Bax (a, b) and Bcl-2 (c, d) by Western blot. PQ-induced apoptosis was evaluated by TUNEL-like staining (e, f) 72 h after PQ administration. TO901317L: TO901317 at the low dose of 5 mg/kg; TO901317H: TO901317 at the high dose of 20 mg/kg. The values presented are the mean ± SD (). versus PQ group; versus PQ + TO901317L group.