Design, Development, and Optimization of Dexibuprofen Microemulsion Based Transdermal Reservoir Patches for Controlled Drug Delivery

Table 2

The levels, composition, and responses of dexibuprofen microemulsion formulations computed by simplex lattice design.

Formulation	(%)	(%)	(%)	pH	Conductance; (µS/cm)	Viscosity; (mPaS)	Refractive index	Size; (nm)	PI	Drug content; (%)
F1	5	60	25	4.66 ± 0.04	29 ± 0.17	360 ± 15.27	1.44 ± 0.001	138–175 ± 30	0.56	99.4 ± 2.48
F2	5	55	30	4.74 ± 0.09	32.7 ± 0.81	280 ± 20.8	1.44 ± 0.001	119.8 ± 13	0.4	100.8 ± 1.96
F3	5	65	20	4.94 ± 0.04	32.32 ± 0.92	250 ± 20.8	1.44 ± 0.001	221.6 ± 30	0.577	100.53 ± 0.83
F4	10	60	20	5.48 ± 0.26	12.94 ± 0.04	240 ± 15.27	1.45 ± 0.001	163–240 ± 30	0.36	97.9 ± 1.38
F5	10	55	25	5.46 ± 0.02	12.71 ± 0.02	110 ± 15.27	1.45 ± 0.001	160–186 ± 30	0.56	100.2 ± 0.35
F6	15	55	20	5.21 ± 0.04	20.13 ± 0.11	280 ± 20	1.45 ± 0.002	188–205 ± 40	0.35	99 ± 3.8