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BioMed Research International
Volume 2017, Article ID 4684962, 17 pages
https://doi.org/10.1155/2017/4684962
Research Article

Pharmacokinetics, Tissue Distribution, and Metabolism Study of Icariin in Rat

1Guangzhou ImVin Pharmaceutical Co., Ltd., Guangzhou 510663, China
2Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510120, China

Correspondence should be addressed to Liu Yang; moc.liamtoh@979uilgnay

Received 6 June 2017; Accepted 4 October 2017; Published 13 November 2017

Academic Editor: Stephen H. Safe

Copyright © 2017 Shunjun Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. X. Wang, Y. He, B. Guo et al., “In vivo screening for anti-osteoporotic fraction from extract of herbal formula xianlinggubao in ovariectomized mice,” PLoS ONE, vol. 10, no. 2, Article ID e0118184, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. R.-H. Liu, X. Kang, L.-P. Xu et al., “Effects of the combined extracts of Herba Epimedii and Fructus Ligustri Lucidi on bone mineral content and bone turnover in osteoporotic rats,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, article 112, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. B. C. L. Chan, H. Y. Lee, W. S. Siu et al., “Suppression of mast cell activity contributes to the osteoprotective effect of an herbal formula containing Herba Epimedii, Fructus Ligustri Lucidi and Fructus Psoraleae,” Journal of Pharmacy and Pharmacology, vol. 66, no. 3, pp. 437–444, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. S. C. W. Sze, Y. Tong, T. B. Ng, C. L. Y. Cheng, and H. P. Cheung, “Herba Epimedii: anti-oxidative properties and its medical implications,” Molecules, vol. 15, no. 11, pp. 7861–7870, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Niu, “Action of the drug Herba Epimedii on testosterone of the mouse plasma and its accessory sexual organ before and after processing,” China Journal of Chinese Materia Medica, vol. 14, no. 9, pp. 530–574, 1989. View at Google Scholar · View at Scopus
  6. F.-X. Liu, S. Sun, and Z.-Z. Cui, “Analysis of immunological enhancement of immunosuppressed chickens by Chinese herbal extracts,” Journal of Ethnopharmacology, vol. 127, no. 2, pp. 251–256, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. J.-H. Kim, Y.-J. Mun, S.-J. Im, J.-H. Han, H.-S. Lee, and W.-H. Woo, “Effects of the aqueous extract of Epimedii Herba on the antibody responses in mice,” International Immunopharmacology, vol. 1, no. 5, pp. 935–944, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. X. Yu, Y. Tong, X.-Q. Han et al., “Anti-angiogenic activity of Herba Epimedii on zebrafish embryos in vivo and HUVECs in vitro,” Phytotherapy Research, vol. 27, no. 9, pp. 1368–1375, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. D.-C. Zhang, J.-L. Liu, Y.-B. Ding, J.-G. Xia, and G.-Y. Chen, “Icariin potentiates the antitumor activity of gemcitabine in gallbladder cancer by suppressing NF-κB,” Acta Pharmacologica Sinica, vol. 34, no. 2, pp. 301–308, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Kong, J. Liu, J. Wang et al., “Icariin inhibits TNF-α/IFN-γ induced inflammatory response via inhibition of the substance P and p38-MAPK signaling pathway in human keratinocytes,” International Immunopharmacology, vol. 29, no. 2, pp. 401–407, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Shao, J. Shen, M. Wang et al., “Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model,” Biomaterials, vol. 60, pp. 92–99, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. Q. Wei, J. Zhang, G. Hong et al., “Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ERα-Wnt/β-catenin signaling pathway,” Biomedicine & Pharmacotherapy, vol. 84, pp. 931–939, 2016. View at Publisher · View at Google Scholar · View at Scopus
  13. S.-Q. Zhang, W.-J. Cai, J.-H. Huang et al., “Icariin, a natural flavonol glycoside, extends healthspan in mice,” Experimental Gerontology, vol. 69, pp. 226–235, 2015. View at Publisher · View at Google Scholar
  14. M. N. Makarova, O. N. Pozharitskaya, A. N. Shikov, S. V. Tesakova, V. G. Makarov, and V. P. Tikhonov, “Effect of lipid-based suspension of Epimedium koreanum Nakai extract on sexual behavior in rats,” Journal of Ethnopharmacology, vol. 114, no. 3, pp. 412–416, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Chen, J. Wang, X. Jia, X. Tan, and M. Hu, “Role of intestinal hydrolase in the absorption of prenylated flavonoids present in yinyanghuo,” Molecules, vol. 16, no. 2, pp. 1336–1348, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. J. J. Yu, Y. J. Liu, S. J. Xu, S. Sun, Y. J. Xu, and L. Yang, “Simultaneous quantitative determination of four epimedium flavonoids in rat urine by LC-MS/MS,” Traditional Chinese Drug Research & Clinical Pharmacology, vol. 27, no. 4, pp. 537–541, 2016. View at Google Scholar
  17. Y. Lu, N. Li, Y. Deng et al., “Simultaneous determination of icariin, naringin and osthole in rat plasma by UPLC-MS/MS and its application for pharmacokinetic study after oral administration of Gushudan capsules,” Journal of Chromatography B, vol. 993-994, pp. 75–80, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Wang, X. Huang, X. Wang, Y. Zhang, R. Wu, and D. Shou, “Pipette tip solid-phase extraction and high-performance liquid chromatography for the determination of flavonoids from Epimedii herba in rat serum and application of the technique to pharmacokinetic studies,” Journal of Chromatography B, vol. 990, pp. 64–72, 2015. View at Publisher · View at Google Scholar · View at Scopus