Research Article
Pharmacokinetics, Tissue Distribution, and Metabolism Study of Icariin in Rat
Table 2
Intra- and interday accuracy and precision for the determination of icariin in plasma and tissue samples (
, 6 replicates per day for 3 days).
| c | Conc. | Interday | Intraday | ng/mL | RE (%) | CV (%) | RE (%) | CV (%) |
| Plasma | 2 | −0.394 | 13.4 | −0.887 | 3.50 | 20 | −5.18 | 1.56 | −4.85 | 2.25 | 400 | −3.28 | 1.50 | −2.76 | 2.47 |
| Liver | 2 | 0.690 | 1.55 | −0.197 | 4.64 | 20 | −0.528 | 9.59 | −0.198 | 1.85 | 400 | −1.03 | 10.4 | −1.17 | 1.62 |
| Heart | 2 | −0.309 | 4.25 | −4.83 | 3.22 | 20 | 4.09 | 1.61 | 4.95 | 2.46 | 400 | −3.65 | 2.19 | −2.57 | 1.59 |
| Spleen | 2 | −2.14 | 9.00 | −3.35 | 7.63 | 20 | 3.96 | 5.09 | 3.46 | 2.25 | 400 | −0.313 | 4.75 | 0 | 1.98 |
| Lung | 2 | −6.80 | 13.7 | −13.3 | 4.72 | 20 | −2.05 | 14.1 | −8.52 | 2.67 | 400 | −9.30 | 10.2 | −1.26 | 1.11 |
| Kidney | 2 | 4.73 | 5.36 | 3.94 | 5.36 | 20 | 3.99 | 13.3 | 7.43 | 2.77 | 400 | −6.49 | 13.6 | −5.73 | 1.49 |
| Brain | 2 | −13.1 | 9.48 | −12.3 | 4.74 | 20 | 3.27 | 5.59 | 0.792 | 1.40 | 400 | −3.28 | 3.56 | −3.36 | 2.12 |
| Testicle | 2 | −4.20 | 3.25 | −2.36 | 4.60 | 20 | 0.538 | 4.93 | 3.07 | 2.69 | 400 | −0.379 | 5.79 | 2.57 | 4.02 |
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