Pharmacokinetics, Tissue Distribution, and Metabolism Study of Icariin in Rat

Table 2

Intra- and interday accuracy and precision for the determination of icariin in plasma and tissue samples (, 6 replicates per day for 3 days).

c	Conc.	Interday		Intraday
	ng/mL	RE (%)	CV (%)	RE (%)	CV (%)
Plasma	2	−0.394	13.4	−0.887	3.50
	20	−5.18	1.56	−4.85	2.25
	400	−3.28	1.50	−2.76	2.47
Liver	2	0.690	1.55	−0.197	4.64
	20	−0.528	9.59	−0.198	1.85
	400	−1.03	10.4	−1.17	1.62
Heart	2	−0.309	4.25	−4.83	3.22
	20	4.09	1.61	4.95	2.46
	400	−3.65	2.19	−2.57	1.59
Spleen	2	−2.14	9.00	−3.35	7.63
	20	3.96	5.09	3.46	2.25
	400	−0.313	4.75	0	1.98
Lung	2	−6.80	13.7	−13.3	4.72
	20	−2.05	14.1	−8.52	2.67
	400	−9.30	10.2	−1.26	1.11
Kidney	2	4.73	5.36	3.94	5.36
	20	3.99	13.3	7.43	2.77
	400	−6.49	13.6	−5.73	1.49
Brain	2	−13.1	9.48	−12.3	4.74
	20	3.27	5.59	0.792	1.40
	400	−3.28	3.56	−3.36	2.12
Testicle	2	−4.20	3.25	−2.36	4.60
	20	0.538	4.93	3.07	2.69
	400	−0.379	5.79	2.57	4.02