Curcumin Analogue CA15 Exhibits Anticancer Effects on HEp-2 Cells via Targeting NF-κB

Figure 2

CA15 suppressed proliferation and migration in HEp-2 cells. (a) HEp-2 cells were treated with different concentrations (0–20 μM) of CA15, 20 μM Cur, and 20 μM BMS for 24 h. Cell proliferation was evaluated with colony formation assay. (b) HEp-2 cells were treated with different concentrations (0–20 μM) of CA15, 20 μM Cur, and 20 μM BMS for 24 h. Cell migration was examined using Transwell migration chambers and then observed under a microscope (magnification ×200). The graph displays means ± SEM of 3 independent experiments. < 0.05, < 0.01, and versus DMSO group. Cur: curcumin; BMS: BMS-345541.

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