miRNAs in Prediction of Prognosis in Clear Cell Renal Cell Carcinoma

Table 2

The miRNAs predicting the prognosis of ccRCC.

miRNA	Changes	Ref	Functional mechanism
miR-23B/27B	Downregulation	[14]	Inhibiting cell proliferation, migration, and invasion
miR-29b	Upregulation	[15]	Promoting apoptosis; inhibiting cell proliferation and invasion by regulating the expression of KIF1B
miR-124-3	ND	[17]	In relation to cyclin D kinase 6
miR-27a-3p	Upregulation	[18]	Inhibiting cell proliferation, migration, and invasion
miR-30a	Downregulation	[19]	Targeting DLL4 and decreasing tumor microvessel density
miR-646	Upregulation	[20]	Inhibiting cell proliferation and cell cycle by targeting NOB1
miR-30c	Upregulation	[21]	Regulating cell motility and adhesion
miR-194	Upregulation	[10]	Involved in ccRCC progression by targeting HIF1A, MDM2, PIK3R2, MAPK1, IGF1R, BCL2, ITGB1, and CRK
miR-126	Upregulation	[9]	Targeting SPRED1, IGF1R, BCL2, CRK, CCNE2, PIK3R2; involved in ccRCC progression through HIF-1, VEGF, mTOR, and PI3K–Akt signaling pathways
mir-210	Upregulation	[23]	Involved in mitochondrial metabolism, stem cell survival, cell cycle regulation, angiogenesis, and cell-cell adhesion
miR-203	Upregulation	[24]	Inhibiting cell proliferation, migration, and invasion by directly targeting FGF2
miR-217	Upregulation	[27]	Inhibiting cell proliferation and migration
miR-187	Upregulation	[28]	Inhibiting cell proliferation, migration, and tumor growth by directly targeting B7-H3
miR-129-3p	Downregulation	[29]	Inhibiting cell migration and invasion by downregulating SOX4, p-FAK, MMP2, and MMP-9
miR-141-3p; miR-145-5p	Downregulation	[32]	Inhibiting cell migration by regulating HS6ST2 and LOX