Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research

Table 3

This table summarizes neuroprotective drugs, details of clinical trials completed in AIS, route (i.v.: intravenous; p.o.: per-oral), phases, number of patients enrolled, and clinical trial number.

Summary of neuroprotective drug trials
Drug	Dose	Time window	Phase	Number of patients	Clinical trial number	Citation
GSK249320	i.v. escalation cohorts 1, 5, and 15 mg/kg	24–72 hours	2	42	NCT00833989	[12]
GSK249320	i.v. escalation doses of 0.04, 0.4, 1.2, 3.5, 10, and 25 mg/kg	Healthy volunteers	1	47	NCT00622609	[13]
Lovastatin	1, 3, 6, 8, and 10 mg/kg per day for 3 days	24 hours	1	33	NCT00243880	[14]
Donepezil	5 mg/day p.o. for 30 days, increased to 10 mg/day for 60 days	≤24 hours	2a	33	NCT00805792	[15]