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BioMed Research International
Volume 2017 (2017), Article ID 4875026, 7 pages
Research Article

Serum Vaspin Concentration in Elderly Type 2 Diabetes Mellitus Patients with Differing Body Mass Index: A Cross-Sectional Study

1Department of Geriatric Medicine, Capital Medical University, Xuan Wu Hospital, Beijing 100053, China
2Department of Endocrine, Capital Medical University, Xuan Wu Hospital, Beijing 100053, China

Correspondence should be addressed to Wei Yang

Received 14 January 2017; Revised 5 April 2017; Accepted 9 April 2017; Published 3 May 2017

Academic Editor: Flavia Prodam

Copyright © 2017 Wei Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims. This study was to evaluate the association of serum vaspin concentrations with body mass index (BMI) among elderly patients (>60 years old). Methods. A total of 227 elderly individuals included 76 healthy with normal glucose tolerance, which divided into normal weight control (BMI < 25, ) and overweight or obese control (BMI ≥ 25, ) subgroups, and 150 T2DM patients, which divided into normal weight diabetes (BMI < 25, ), overweight diabetes (30 > BMI ≥ 25, ), and obese diabetes (BMI ≥ 30, ) subgroups. Relevant parameters were matched for age and gender ratio. Serum vaspin concentrations were measured by enzyme-linked immunosorbent assay. Results. Serum vaspin concentration was significantly higher in the T2DM than the healthy ( versus , ). In the diabetic patients, the vaspin concentration was significantly higher in the obese group than the normal weight group ( versus , ). In addition, the concentration of vaspin in normal weight T2DM was higher than in healthy control group with normal weight ( versus , ). Multiple regression analysis revealed that BMI was independent factors influencing the serum vaspin concentration in all participants. Conclusion. Vaspin may play an important compensatory role in obesity and insulin resistance in elderly people. The clinical trial registration number is ChiCTR-OPC-14005698.