Increased Circulating Endothelial Microparticles Associated with PAK4 Play a Key Role in Ventilation-Induced Lung Injury Process

Figure 1

Pulmonary edema induced by VILI. (a). Hematoxylin-eosin (HE) staining of lung tissues. In both C57BL/6 and TLR4KO mice, the alveolar wall was thickened after mechanical ventilation (MV), while Tetramethylpyrazine (TMP) alleviated the thickening process. (b). Wet/dry (W/D) values of lung homogenates. In both C57BL/6 and TLR4KO mice, MV enhanced the W/D values, while TMP alleviated the enhancement. Differences are shown between mechanical ventilation- (MV-) treated mice and Tetramethylpyrazine + mechanical ventilation- (TMP + MV-) treated mice in the same group. versus the control mice of the same strain. versus the TMP + MV-treated mice of the same strain. In both C57BL/6 and TLR4KO mice, MV resulted in pulmonary edema and TMP could alleviate the edema process.

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