Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Activates Type I Interferon Signals in Lupus Nephritis

Table 1

The index levels of renal damage in different groups of MRL/lpr mice.

	24-hour urinary albumin (mg)	Scr (mmol/L)	BUN (μmol/L)
MRL/MPJ		5.52 ± 0.81^†
Control	8.20 ± 1.12	9.845 ± 1.33	103.96 ± 12.18
TWEAK-shRNA		7.13 ± 0.91^†
Control-shRNA	8.50 ± 1.32	10.06 ± 1.21	95.93 ± 11.52

Data is presented as mean ± standard deviation. Control, MRL/lpr mice treated with normal saline; TWEAK-shRNA, MRL/lpr mice treated with LV-TWEAK-shRNA; control-shRNA, MRL/lpr mice treated with LV-control-shRNA. The numbers of MRL/MPJ, control, TWEAK-shRNA, and control-shRNA mice were 7, 10, 12, and 12, respectively. compared with control. values have been adjusted for multiplicity.