MiR-222 in Cardiovascular Diseases: Physiology and Pathology

Figure 1

Multiple physiological functions of miR-222 (miR-222 has been found to participate in multiple physiological functions in cardiovascular system. In cardiac myocyte, miR-222 could promote cardiomyocytes growth, proliferation, and survival through directly targeting P27, HIPK-1, HIPK-2, and CITED-4 in traditional exercise pathway. In stem cell, miR-222 could promote CSCs transformation. In umbilical vein endothelial cells, miR-222 could exert angiogenesis function by targeting c-Kit).