MiR-222 in Cardiovascular Diseases: Physiology and Pathology

Figure 2

Multiple pathological functions of miR-222 (miR-222 has been found to participate in multiple pathological functions in cardiovascular system. In myocardium, miR-222 could (1) promote cardiomyocyte proliferation and reduce cardiomyocyte apoptosis through P27 after ischemic injury; (2) inhibit autophagy through mTOR; (3) regulate blood vessels remolding through c-Kit and eNOS; (4) regulate ICAM-1 and IRF-2 to inhibit inflammation. In blood vessels, miR-222 could (1) stable the plaque and suppress the inflammation and (2) inhibited the proliferation of vascular smooth muscle by targeting p27).