CD147 as a Novel Prognostic Biomarker for Hepatocellular Carcinoma: A Meta-Analysis

Table 4

Meta-analyses of CD147 Expression classified by clinicopathological parameters.

Variables	Number of studies	Model	OR (95% CI)	value	Heterogeneity (, value)
Tumor size (≤5 cm/>5 cm)	5	Random	0.38 (0.14, 1.03)	0.06	88%, <0.00001
Cirrhosis (absent/present)	4	Random	0.44 (0.13, 1.45)	0.18	60%, 0.06
Differentiation (well/middle or low)	5	Random	0.54 (0.15, 1.96)	0.35	83%, <0.0001
TMNI-	6	Random	0.18 (0.04, 0.85)	0.03	91%, <0.00001
Lymph node metastasis (yes/no)	2	Fixed	3.60 (0.96, 13.53)	0.06	0%, 0.60
HBsAg (positive/negative)	4	Fixed	1.06 (0.64, 1.74)	0.82	31%, 0.23
Venous invasion (present/absent)	2	Random	6.29 (1.70, 23.20)	0.006	74%, 0.05
Serum AFP level (≤25/≥25g/L)	3	Random	0.28 (0.04, 1.89)	0.19	85%, 0.001