Obesity Induces Artery-Specific Alterations: Evaluation of Vascular Function and Inflammatory and Smooth Muscle Phenotypic Markers

Table 3

Maximal response (mN/mm) and sensitivity (log EC50) to relaxing and contractile agents in small mesenteric arteries and thoracic aorta from control and obese mice.

	Maximal response		log EC50
	Control mice	Obese mice	Control mice	Obese mice
Mesenteric arteries
Acetylcholine	90.50 ± 2.26	90.91 ± 1.81
SNP	92.67 ± 2.01	89.92 ± 2.42
KCl	1.61 ± 0.12		1.72 ± 0.05	1.46 ± 0.12
U46619	1.91 ± 0.19
Noradrenaline	2.21 ± 0.22
Serotonin	0.74 ± 0.12
Thoracic aorta
Acetylcholine	75.94 ± 4.51	75.56 ± 5.91
SNP	95.55 ± 1.75	96.01 ± 2.21
KCl	2.88 ± 0.26	2.74 ± 0.19		2.04 ± 0.06
U46619	3.90 ± 0.17	3.68 ± 0.11
Noradrenaline	1.99 ± 0.13
Serotonin	2.61 ± 0.12	2.44 ± 0.10

SNP: sodium nitroprusside. KCl: potassium chloride. Data are expressed as mean ± SEM. Unpaired -test: versus control mice. (KCl and serotonin). –12 (acetylcholine, SNP, U46619, and noradrenaline).