Obesity Induces Artery-Specific Alterations: Evaluation of Vascular Function and Inflammatory and Smooth Muscle Phenotypic Markers

Table 4

Maximal response (mN/mm) and sensitivity (log EC50) to noradrenaline in small mesenteric arteries and thoracic aorta incubated with L-NAME, L-NIL, and indomethacin.

	Maximal response		log EC50
	Control mice	Obese mice	Control mice	Obese mice
Mesenteric arteries
Noradrenaline	2.17 ± 0.26
+L-NAME	2.65 ± 0.21	2.36 ± 0.36^#
+L-NIL	2.54 ± 0.28
+Indomethacin	2.32 ± 0.09
Thoracic aorta
Noradrenaline	1.69 ± 0.19
+L-NAME	4.05 ± 0.39^#	3.93 ± 0.23^#
+L-NIL	3.30 ± 0.16^#	2.95 ± 0.28^#
+Indomethacin	1.89 ± 0.19	1.23 ± 0.26^#

Data are expressed as mean ± SEM. One-way ANOVA: versus control mice; versus noradrenaline. –12.