Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017, Article ID 5045827, 11 pages
https://doi.org/10.1155/2017/5045827
Research Article

The Critical Role of Long Noncoding RNA in Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells

1Department of Endodontics, Stomatological Hospital of Southern Medical University and Guangdong Provincial Stomatological Hospital, Guangzhou 510280, China
2Department of Oral Surgery, Stomatological Hospital of Southern Medical University and Guangdong Provincial Stomatological Hospital, Guangzhou 510280, China

Correspondence should be addressed to JianJiang Zhao; moc.361@oahz_gnaijnaij

Received 14 November 2016; Accepted 2 April 2017; Published 27 April 2017

Academic Editor: Milena Fini

Copyright © 2017 Xiaoling Qiu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. E. Elsalanty and D. G. Genecov, “Bone grafts in craniofacial surgery,” Craniomaxillofacial Trauma and Reconstruction, vol. 2, no. 3, pp. 125–134, 2009. View at Publisher · View at Google Scholar
  2. M. Fröhlich, W. L. Grayson, L. Q. Wan, D. Marolt, M. Drobnic, and G. Vunjak-Novakovic, “Tissue engineered bone grafts: biological requirements, tissue culture and clinical relevance,” Current Stem Cell Research & Therapy, vol. 3, no. 4, pp. 254–264, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Al-Nbaheen, R. vishnubalaji, D. Ali et al., “Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential,” Stem Cell Reviews and Reports, vol. 9, no. 1, pp. 32–43, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Cui, S. M. Xu, D. D. Ma, and B. L. Wu, “The effect of TRPM7 suppression on the proliferation, migration and osteogenic differentiation of human dental pulp stem cells,” International Endodontic Journal, vol. 47, no. 6, pp. 583–593, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Mo, S. Wang, Y. Zhou, H. Li, and Y. Wu, “Mesenchymal stem cell subpopulations: phenotype, property and therapeutic potential,” Cellular and Molecular Life Sciences, vol. 73, no. 17, pp. 3311–3321, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Cui, S. Xu, D. Ma et al., “The role of integrin-α5 in the proliferation and odontogenic differentiation of human dental pulp stem cells,” Journal of Endodontics, vol. 40, no. 2, pp. 235–240, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Gebler, O. Zabel, and B. Seliger, “The immunomodulatory capacity of mesenchymal stem cells,” Trends in Molecular Medicine, vol. 18, no. 2, pp. 128–134, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Kashi, L. Henderson, A. Bonetti, and P. Carninci, “Discovery and functional analysis of IncRNAs: methodologies to investigate an uncharacterized transcriptome,” Biochimica et Biophysica Acta---Gene Regulatory Mechanisms, vol. 1859, pp. 3–15, 2016. View at Google Scholar
  9. J. Cao, “The functional role of long non-coding RNAs and epigenetics,” Biological Procedures Online, vol. 16, article 11, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Lv, Y. Sun, and Y. Zhang, “MiR-133 is involved in estrogen deficiency-induced osteoporosis through modulating osteogenic differentiation of mesenchymal stem cells,” Medical Science Monitor, vol. 21, pp. 1527–1534, 2015. View at Publisher · View at Google Scholar
  11. O. Wapinski and H. Y. Chang, “Long noncoding RNAs and human disease,” Trends in Cell Biology, vol. 21, no. 6, pp. 354–361, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. W. Zhuang, X. Ge, S. Yang et al., “Upregulation of lncRNA MEG3 promotes osteogenic differentiation of mesenchymal stem cells from multiple myeloma patients by targeting BMP4 transcription,” Stem Cells, vol. 33, no. 6, pp. 1985–1997, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Jin, L. Jia, Y. Huang et al., “Inhibition of lncRNA MIR31HG promotes osteogenic differentiation of human adipose-derived stem cells,” Stem Cells, In press.
  14. E. A. Gibb, E. A. Vucic, K. S. S. Enfield et al., “Human cancer long non-coding RNA transcriptomes,” PLoS ONE, vol. 6, no. 10, Article ID e25915, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Huang, N. Liu, J. P. Wang et al., “Regulatory long non-coding RNA and its functions,” Journal of Physiology and Biochemistry, vol. 68, no. 4, pp. 611–618, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. J. R. Evans, F. Y. Feng, and A. M. Chinnaiyan, “The bright side of dark matter: lncRNAs in cancer,” Journal of Clinical Investigation, vol. 126, no. 8, pp. 2775–2782, 2016. View at Publisher · View at Google Scholar
  17. S. Uchida and S. Dimmeler, “Long noncoding RNAs in cardiovascular diseases,” Circulation Research, vol. 116, no. 4, pp. 737–750, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Wang, Y. Wang, Z. Li, Z. Li, and B. Yu, “Differential expression of long noncoding ribonucleic acids during osteogenic differentiation of human bone marrow mesenchymal stem cells,” International Orthopaedics, vol. 39, no. 5, pp. 1013–1019, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Malaval, A. K. Gupta, and J. E. Aubin, “Leukemia inhibitory factor inhibits osteogenic differentiation in rat calvaria cell cultures,” Endocrinology, vol. 136, no. 4, pp. 1411–1418, 1995. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Thysen, F. Cailotto, and R. Lories, “Osteogenesis induced by frizzled-related protein (FRZB) is linked to the netrin-like domain,” Laboratory Investigation, vol. 96, no. 5, pp. 570–580, 2016. View at Publisher · View at Google Scholar
  21. Y. Huang, Y. Zheng, L. Jia, and W. Li, “Long noncoding RNA H19 promotes osteoblast differentiation via TGF-β1/Smad3/HDAC signaling pathway by deriving miR-675,” Stem Cells, vol. 33, no. 12, pp. 3481–3492, 2015. View at Publisher · View at Google Scholar
  22. Y. Cui, S. Lu, H. Tan, J. Li, M. Zhu, and Y. Xu, “Silencing of long non-coding RNA NONHSAT009968 ameliorates the Staphylococcal protein A-Inhibited osteogenic differentiation in human bone mesenchymal stem cells,” Cellular Physiology and Biochemistry, vol. 39, no. 4, pp. 1347–1359, 2016. View at Publisher · View at Google Scholar