Structure and Function of Trypsin-Loaded Fibrinolytic Liposomes

Figure 4

The surface morphology of the trypsin-free ((a) and (b)) and trypsin-loaded ((c) and (d)) vesicles by freeze fracture TEM. (a) Three types of fractures can be observed: (A) convex fractured surfaces of the vesicles protruding from the aqueous medium, (B) concave areas of the imprints of vesicles broken out, and (C) bottom parts of remaining vesicles broken through entirely. (b) The inner surface of a vesicle, broken through entirely, is typically smooth. All three types of fractured surfaces are observed in the trypsin-loaded vesicles (c), but the inner surface contains also closely packed grains (d).