Preclinical Studies and Translational Applications of Intracerebral Hemorrhage

Table 1

Common models for studying ICH.

ICH Models	Merits	Demerits
Autologous blood injection	Easy to perform
	Easy to reproduce	Needle trail reflux
	Hematoma size fixed	Cannot mimic rebleeding
	Mimics lobar hemorrhage	Short edema peak time
Collagenase injection	Mimics rebleeding and hematoma expansion	Possible cellular toxicity
	No reflux needle trail Simulating perforating artery rupture	Inconsistent hemorrhage
		Excessive neural damage
Microballoon inflation	For studying mass effect	Minimal damage observed
	Injury confined to inflation site	Only for simulating mass effect