Preclinical Studies and Translational Applications of Intracerebral Hemorrhage

Table 2

Preclinical drugs and their potential function.

Experimental drugs	Target	Function
Curcumin	Inhibit MMP-9, suppress TNF-α and iNOS	Neuroprotection, edema alleviation
Progesterone	Inhibit MMP-9, restore (BDNF)mRNA, NaK-ATPase mRNA, MAP, and ChAT	Neuroprotection, decrease glial cell and edema formation
(−)-Epicatechin	Upregulate Nrf2	Alleviates oxidative stress,
Prostaglandin E2	Downregulate HMGB1, interleukin-1β and Src kinase expression	Prevent edema formation, neuroprotection
Melatonin	Downregulate MMP-2 and MMP-9	Neuroprotection and edema alleviation
Imatinib	Downregulate PDGFR-β	Neuroprotection
Sparstolonin	Inhibit TLR2/TLR4 and NF‐κB	Neuroprotection
Dexamethasone	Increase Bcl-2/Bax, downregulate ICAM-1 and MMP-9	Edema alleviation
Aprotinin	Inhibit plasma kallikrein	Prevents rebleeding and edema formation