Role of Vascular Endothelial Cells in Disseminated Intravascular Coagulation Induced by Seawater Immersion in a Rat Trauma Model

Table 1

Category of differentially expressed genes in the VECs of rats in the SW group according to the PCR array.

Category	Differentially expressed gene ()		No change gene ()
	Upregulated	Downregulated
Permeability and vessel tone	11	1	0	1.00
Angiotensin system	Agt, Agtr1	Blr1		1.00
NO system	Nos2, Nos3			1.00
Prostacyclin system	Ptgis			1.00
Endothelin system	Ednra			1.00
Oxidoreductase activity	Nos2, Nos3, Sod1, Xdh			1.00
Regulation of blood pressure	Agtr1, Edn1, Edn2, Ednra, Npr1			1.00
Regulation of vasoconstriction	Edn1, Edn2			1.00
Angiogenesis	14	0	1	0.93
Negative regulation of angiogenesis	Cxcl4, Plg, Thbs1			1.00
Positive regulation of angiogenesis	Rhob			1.00
Other genes involved in angiogenesis	Angpt1, Col18a1, Fgf1, Fgf2, Flt1, Itgav, Pgf, Serpine1, Tek, Vegfa		Kdr	0.91
Endothelial cell activation	49	12	15	0.80
Adhesion molecules	Cdh5, Col18a1, Cx3cl1, Fn1, Itga5, Itgav, Itgb1, Rhob, Selp, Tek, Thbs1	Ocln, Sell	Icam1, Itgb3, Pecam, Sele, Vcam1	0.72
Extracellular matrix molecules	Ace, Agt, Angpt1, Cdh5, Col18a1, Cx3cl1, Cxcl1, Cxcl2, Edn1, Edn2, Flt1, Fn1, Ifnb1, Il11, Itga5, Itgb1, Mmp1a, Mmp2, Nppb, Npr1, Pdgfra, Cxcl4, Pgf, Plat, Plau, Plg, Ptgis, Selp, Serpine1, Tek, Tfpi, Thbd, Thbs1, Timp1, Tnfsf10, Vegfa, Vwf	Csf2, Sell, Mmp9, Il1b, Ccl5, Ocln, Casp1, Il7, Tnfsf6	Adam17, Ccl2, Cpb2,Il3, Il6, Kdr, Pecam, Sele, Tgfb1, Vcam1	0.82
Cytokine activity	Cx3cl1, Cxcl1, Cxcl2, Ifnb1, Il11, Cxcl4, Tnfsf10	Csf2, Tnf, Tnfsf6, Il1b, Ccl5, Il7	Ccl2, Il3, Il6	0.81
Thrombin activity	Anxa5, Ecgf1, Plat, Plau, Plg, Serpine1			1.00
Vascular endothelial growth factor Receptor activity	Angpt1, Flt1, Pdgfra		Kdr	0.75
Other genes involved in cell growth	Bax, Col18a1, Cxcl1, Ednra, Fgf1, Il11, Itgav, Itgb1, Nos2, Cxcl4, Pgf, Rhob, Tek, Vegfa, Xdh	Csf2, Blr1, Il1b, Il7	Casp3, Il3, Il6, Itgb3, Kit, Pecam, Tgfb1	0.73
Endothelial cell injury	18	8	13	0.67
Response to stress	Bax, Bcl2l1, Cx3cl1, Cxcl1, Cxcl2, Cxcl4, Fn1, Tnfrsf6, Ifnb1, Nos2, Selp, Sod1, Tnfsf10	Csf2, Il1b, Ccl5, Casp1, Il7, Tnf, Tnfsf6	Casp3, Ccl2, Il3, Il6, Kit, Pecam, Tgfb1	0.74
Antiapoptosis	Bcl2l1, Vegfa	Birc1b	Bcl2	0.75
Caspase activation	Bax	Casp1	Casp3, Casp6, Cflar	0.40
Induction of apoptosis	Bax, Plg, Tnfrsf6	Casp1	Casp3	0.80
Other apoptosis genes	Bcl2l1, Col18a1, Rhob, Tnfsf10	Tnfsf6	Cradd, Il6, Ripk1, Tnfaip3	0.56