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BioMed Research International
Volume 2017 (2017), Article ID 5198723, 8 pages
https://doi.org/10.1155/2017/5198723
Review Article

Cell-Based Models for Development of Antiatherosclerotic Therapies

1Institute of General Pathology and Pathophysiology, Moscow, Russia
2INSERM UMR_S 1166-ICAN Faculté de Médecine Pitié-Salpêtrière, Paris, France
3Institute for Atherosclerosis Research, Skolkovo Innovation Center, Moscow, Russia

Correspondence should be addressed to Emile R. Zakiev

Received 9 October 2016; Accepted 11 January 2017; Published 14 February 2017

Academic Editor: Fabrizio Montecucco

Copyright © 2017 Emile R. Zakiev et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The leading cause of death worldwide is cardiovascular disease. Among the conditions related to the term, the most prominent one is the development of atherosclerotic plaques in the walls of arteries. The situation gets even worse with the fact that the plaque development may stay asymptomatic for a prolonged period of time. When it manifests as a cardiovascular disorder, it is already too late: the unfortunate individual is prescribed with a plethora of synthetic drugs, which are of debatable efficacy in the prevention of atherosclerotic lesions and safety. Cell models could be useful for the purpose of screening substances potentially effective against atherosclerosis progression and effective in reduction of already present plaques. In this overview, we present studies making use of in vitro and ex vivo models of atherosclerosis development that can prove valuable for clinical applications.