Cell-Based Models for Development of Antiatherosclerotic Therapies

Figure 1

Targets of atherosclerotic and antiatherogenic drug therapy. The figure schematically represents lumen of blood vessel and a vessel wall cell highlighting possible targets for antiatherosclerotic therapy. The first target (target 1) is atherogenic modification (desialylation) of the LDL particle in blood. The prevention of LDL modification may be an approach to antiatherosclerosis therapy. The second approach may be the selective removal of modified LDL from blood (target 2). The third approach may be based on the prevention of modified LDL accumulation in arterial cells (target 3). Additionally, another approach is the removal of excess lipids from foam cells (target 4). Taken with permission from [9].