Review Article

Emerging and Neglected Infectious Diseases: Insights, Advances, and Challenges

Table 1

Some past emerging infectious disease epidemics and probable factors for outbreak.

YearEmerging diseasePathogenic agentMain probable factor

1958Argentine haemorrhagic feverArenavirusJunin virusChanges in agricultural practices of corn harvest (maize mechanization)

1981Acquired immunodeficiency syndrome (AIDS)Human immunodeficiency virusSexual contact/exposure to blood or tissues of an infected person

1959Bolivian haemorrhagic fever (BHF)ArenavirusMachupo virusPopulation increase of rats gathering food

1983Crimean-Congo haemorrhagic feverCCHF virusEcological changes favouring increased human exposure to ticks of sheep and small wild animals

1996Haemorrhagic colitisEscherichia coli O157:H7Ingestion of contaminated food, undercooked beef, and raw milk

1976MalariaPlasmodium falciparumHuman behaviour/rainfall and drainage problems/mosquito breeding/neglect of eradication policy, economics, and growing interchange of populations

1993Hantavirus pulmonary syndrome (HPS)HantavirusSin Nombre virusHuman invasion of virus ecological niche; close contact with infected rodent natural reservoir; inhalation of infectious aerosolized rodent faces and urine

1997Highly pathogenic avian influenza (HPAI)H5N1 virusAnimal-animal influenza virus gene reassortment; emergence of H5N1 avian influenza, extensive chicken farming

1889, 1890, 1918, 1957Pandemic InfluenzaParamyxovirus influenza AAnimal-human virus reassortment and antigenic shift

1969Lassa feverArenavirus Lassa virusHospital exposure to index case—rodent exposure

1956Marburg diseaseFilovirus Marburg virusTrade (and use of wild imported monkeys); use of animal organs for specific purpose

2003Severe acute respiratory syndrome (SARS)SARS CoronavirusHunting and feeding on infected wild animals (viverrids)

1987Rift Valley fever (RVF)Bunyavirus RVF virusDramatic increase in mosquito vector breeding sites (by dam filling); weather (rainfall) and cattle migration (guided by artificial water holes)

1976Ebola haemorrhagic feverFilovirus Ebola virusRainforest penetration by humans/close contact with infected game (hunting) or with host reservoirs (bats)/infected biological products/nosocomial/needle spread

1953Dengue haemorrhagic fever (DHF)Dengue viruses 1, 2, 3, and 4Increasing human population density in cities in a way that favours vector breeding sites (water storage), for example, Aedes aegypti

Note: adapted from “Encyclopedia of Infectious Diseases-Modern Methodologies” [2].