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BioMed Research International
Volume 2017, Article ID 5246853, 11 pages
Review Article

Mitochondrial-Targeted Molecular Imaging in Cardiac Disease

Jinhui Li,1,2,3,4,5 Jing Lu,6,7 and You Zhou1

1Department of Chinese Medicine & Rehabilitation, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
2Department of Nuclear Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
3Zhejiang University Medical PET Center, Zhejiang University, Hangzhou 310009, China
4Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China
5Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China
6Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Hangzhou, China
7Zhejiang Province Key Laboratory of Mental Disorder’s Management, Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Correspondence should be addressed to You Zhou; moc.liamxof@8181uoyuohz

Received 1 January 2017; Accepted 6 February 2017; Published 30 May 2017

Academic Editor: David J. Yang

Copyright © 2017 Jinhui Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study aimed to discuss the role of mitochondrion in cardiac function and disease. The mitochondrion plays a fundamental role in cellular processes ranging from metabolism to apoptosis. The mitochondrial-targeted molecular imaging could potentially illustrate changes in global and regional cardiac dysfunction. The collective changes that occur in mitochondrial-targeted molecular imaging probes have been widely explored and developed. As probes currently used in the preclinical setting still have a lot of shortcomings, the development of myocardial metabolic activity, viability, perfusion, and blood flow molecular imaging probes holds great potential for accurately evaluating the myocardial viability and functional reserve. The advantages of molecular imaging provide a perspective on investigating the mitochondrial function of the myocardium in vivo noninvasively and quantitatively. The molecular imaging tracers of single-photon emission computed tomography and positron emission tomography could give more detailed information on myocardial metabolism and restoration. In this study, series mitochondrial-targeted Tc-, 123I-, and 18F-labeled tracers displayed broad applications because they could provide a direct link between mitochondrial dysfunction and cardiac disease.