Research Article
Computational Exploration for Lead Compounds That Can Reverse the Nuclear Morphology in Progeria
Table 1
Common feature pharmacophore results as generated by the HipHop.
| Hypo number | Features | Rank | Direct Hit | Partial Hit | Max fit |
| 1 | RHHDA | 26.307 | 1111 | 0000 | 4 | 2 | RHHDA | 25.624 | 1111 | 0000 | 4 | 3 | ZHHDA | 25.574 | 1111 | 0000 | 4 | 4 | RHHDA | 25.352 | 1111 | 0000 | 4 | 5 | RHHDA | 25.352 | 1111 | 0000 | 4 | 6 | HHHDA | 24.569 | 1111 | 0000 | 4 | 7 | RHHDA | 24.450 | 1111 | 0000 | 4 | 8 | HHHDA | 24.362 | 1111 | 0000 | 4 | 9 | ZHHDA | 24.290 | 1111 | 0000 | 4 | 10 | RHAA | 24.069 | 1111 | 0000 | 4 |
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R: ring aromatic, H: hydrophobic, HD: hydrogen bond donor, A: hydrogen bond acceptor, Z: zinc binder.
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