Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases

Table 3

Hydroxylysine (Hyl), hydroxylysylpyridinoline (HP), and lysylpyridinoline (LP) levels in small, medium, and large UF and their matched myometrial tissues. Hyl, HP, and LP were measured by HPLC. The numbers of Hyl, HP, and LP were expressed per collagen molecule assuming 300 hydroxyproline residues per triple helix. Data are represented as means ± SEM. Significant difference compared to the small fibroids (). Significant difference compared to the small and medium fibroids ().

	Small; (<20 mm; )		Medium; (20–50 mm; )		Large; (>50 mm; )
	Fibroids	Myometrium	Fibroids	Myometrium	Fibroids	Myometrium
Hyl/collagen (mole/mole)
HP/collagen; (mmole/mole)
LP/collagen; (mmole/mole)
HP+LP/collagen; (mmole/mole)
HP/LP; (mmole/mmole)