The Association between 5HT2A T102C and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease: A Meta-Analysis

Table 1

Characteristics of eligible studies included in the meta-analysis.

Author (year)	Ethnicity	Assessment	Number of patients	BPSD	Positive results	Quality assessment
Pritchard et al. 2008	British	NPI	393	Delusions, hallucinations, agitation, depression, apathy, and AMB	Increased C allele and CC genotype with hallucinations,; delusions, psychosis, and aberrant motor behavior ()	5
Craig et al. 2007	British	NPI	406	Delusions, hallucinations	No significant association was found	5
Lam et al. 2004	Chinese	NPI	87	Delusions, agitation, apathy, and AMB	Increased CC genotype with delusions (), agitation (), apathy (), and AMB ()	3
Holmes et al. 2003	British	CAMDEX	158	Depression	Increased TT and CC genotype with depression ()	4
Holmes et al. 1998	British	CAMDEX/MOUSEPAD	211	Delusions, hallucinations, and agitation	Increased C allele with hallucinations ()	5
Rocchi et al. 2003	Italian	NPI	135	Psychosis	Increased CC genotype () with psychosis	3
Micheli et al. 2006	Italian	NPI/MMSE	208	Depression	No significant association was found	4
Nacmias et al. 2001	Italian	Semistructured interview	83	Psychosis	Increased CC genotype () and C allele () with psychosis	3
Wilkosz et al. 2007	American	DSM-IV	324	Depression	No significant association was found	5

BPSD: behavioral and psychological symptoms of dementia; AMB: aberrant motor behavior; NPI: neuropsychiatric inventory; CAMDEX: Cambridge Examination for Mental Disorders of the Elderly; MMSE: Mini-Mental State Examination; MOUSEPAD: Manchester and Oxford Universities Scale for the Psychological Assessment of Dementia.