The Association between 5HT2A T102C and Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease: A Meta-Analysis

Table 2

Pooled ORs and 95% CIs of the association between 5HT2A T102C and psychological symptoms of Alzheimer’s disease.

Genetic Model	psychological symptoms	Number of studies	Test of association		Model	Test of heterogeneity
			OR [95% CI]	value		value	(%)
C versus T	Delusions	4	1.09 [0.91–1.31]	0.33	F	0.28	22%
	Hallucinations	3	1.18 [0.98–1.44]	0.09	F	0.69	0%
	Agitation/aggression	3	0.99 [0.77–1.26]	0.91	F	0.85	0%
	Depression	4	0.71 [0.48–1.04]	0.08	R	0.04	65%
	Apathy	2	1.31 [0.90–1.89]	0.15	F	0.48	0%
	Aberrant motor behaviour	2	1.26 [0.93–1.71]	0.14	F	0.59	0%
	Psychosis	2	3.19 [2.12–4.79]	<0.00001	F	0.62	0%
TT versus CT/CC	Delusions	4	0.81 [0.59–1.11]	0.20	F	0.80	0%
	Hallucinations	3	0.52 [0.36–0.77]	0.001	F	0.21	35%
	Agitation/aggression	3	0.83 [0.53–1.28]	0.40	F	0.35	4%
	Depression	4	1.29 [0.90–1.87]	0.17	F	0.27	23%
	Apathy	2	0.49 [0.19–1.24]	0.13	R	0.15	51%
	Aberrant motor behaviour	2	0.58 [0.35–0.95]	0.03	F	0.74	0%
	Psychosis	2	0.34 [0.17–0.67]	0.002	F	0.66	0%
CC versus TT/CT	Delusions	4	1.05 [0.80–1.38]	0.74	F	0.15	44%
	Hallucinations	3	1.01 [0.76–1.35]	0.93	F	0.48	0%
	Agitation/aggression	3	0.87 [0.59–1.28]	0.48	F	0.46	0%
	Depression	4	0.64 [0.36–1.13]	0.12	R	0.07	57%
	Apathy	2	1.08 [0.59–1.96]	0.81	F	0.60	0%
	Aberrant motor behaviour	2	0.78 [0.19–3.17]	0.73	R	0.08	66%
	Psychosis	2	7.24 [3.60–14.59]	<0.00001	F	0.21	37%

F: fixed model; R: random model; OR: odd ratio; CI: confidence interval.