MicroRNA-31 Function as a Suppressor Was Regulated by Epigenetic Mechanisms in Gastric Cancer

<div><i>miR-31 was aberrantly downregulated in gastric cancer and cell lines.</i> The relative expression of miR-31 was detected by qRT-PCR analysis in 52 randomly selected gastric cancer tissues paired with adjacent noncancerous gastric tissues (a) and gastric cancer cell lines BGC-823, SGC-7901, and AGS and gastric normal cell line GES-1 (b). The expression of miR-31 was normalized to U6 snRNA <span class="nowrap"><svg height="13.9365pt" id="M7" style="vertical-align:-3.834pt" version="1.1" viewbox="-0.0498162 -10.1025 60.701 13.9365" width="60.701pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M300 -147C201 -63 143 98 143 270S200 602 300 686L282 710C136 610 70 450 70 271V270C70 89 136 -72 282 -170L300 -147Z" id="g113-41"></path></g><g transform="matrix(.0091,0,0,-0.0091,4.498,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 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BioMed Research International

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Figure 1

Figure 1: MicroRNA-31 Function as a Suppressor Was Regulated by Epigenetic Mechanisms in Gastric Cancer 