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BioMed Research International
Volume 2017, Article ID 5356737, 12 pages
https://doi.org/10.1155/2017/5356737
Research Article

The Prognostic Value of HRAS mRNA Expression in Cutaneous Melanoma

1Department of Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
2Beijing Institute of Graphic Communication, Beijing 102600, China
3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing 100142, China

Correspondence should be addressed to Zhongwu Li; moc.liamtoh@iluwhz

Received 9 May 2017; Revised 1 October 2017; Accepted 30 October 2017; Published 19 November 2017

Academic Editor: Peyman Björklund

Copyright © 2017 Xiaohua Wan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study aimed to investigate the prognostic value of HRAS mRNA expression in cutaneous melanoma. Cutaneous melanoma is an aggressive cancer with an increasing incidence. Few studies have focused on the transcriptional level of RAS isoforms (KRAS, NRAS, and HRAS) in cutaneous melanoma. To gain further insight into RAS isoforms at transcriptional level, we obtained the cutaneous melanoma data from cBioPortal and investigated the RAS mRNA expression levels in different stages of melanoma and evaluated their correlation with clinical characteristics and patients’ survival. Furthermore, we retrieved and analyzed the coexpression data and performed pathway enrichment analysis. Totally, 452 cutaneous melanoma cases were included in this study. We found that lower HRAS expression level was associated with longer patient survival. 206 genes that negatively correlated with HRAS expression were positively correlated with KRAS and NRAS expression. In contrast, no gene that positively correlated with HRAS expression was positively correlated with KRAS and NRAS expression. In conclusion, our data showed that transcriptional regulation was different for the three RAS isoforms in cutaneous melanoma. This study highlighted the prognostic value of HRAS mRNA expression and revealed that HRAS greatly differs from KRAS and NRAS at the transcriptional level.