The Prognostic Value of HRAS mRNA Expression in Cutaneous Melanoma

Table 3

Univariate and multivariate Cox regression analyses on overall survival of patients with cutaneous melanoma (TCGA, Provisional).

Variable	Univariate		Multivariate
	HR (95% CI)	value	HR (95% CI)	value
Age (>58 vs. ≤58)	1.674 (1.266~2.215)	<0.001	1.232 (0.854~1.779)	0.265
Gender (female versus male)	1.138 (0.856~1.513)	0.347	1.066 (0.742~1.531)	0.729
AJCC stage (III/IV versus I/II)	1.589 (1.182~2.137)	0.002	1.921 (1.336~2.762)	<0.001
Tumor thickness (>2 mm versus ≤2 mm)	2.237 (1.626~3.076)	<0.001	1.309 (0.881~1.947)	0.183
Ulceration (present versus absent)	2.140 (1.529~2.996)	<0.001	1.787 (1.229~2.600)	0.002
Gene mRNA expression
KRAS (high versus low)	1.091 (0.834~1.428)	0.525	0.915 (0.634~1.319)	0.633
NRAS (high versus low)	1.033 (0.789~1.350)	0.815	0.981 (0.678~1.419)	0.981
HRAS (high versus low)	1.532 (1.163~2.017)	0.002	1.555 (1.066~2.269)	0.022
BRAF (high versus low)	0.910 (0.695~1.193)	0.496	0.794 (0.552~1.143)	0.215