Research Article
The Prognostic Value of HRAS mRNA Expression in Cutaneous Melanoma
Table 4
mRNA expression levels of RAS isoforms according to genetic mutation status of patients with cutaneous melanoma (TCGA, Provisional) (median (95% CI)).
| | Gene (cases) | KRAS | NRAS | HRAS | | mRNA expression | Value | mRNA expression | Value | mRNA expression | Value |
| | KRAS status | | | | | | | | Wild-type (445) | 667.79 (137.53~1487.34) | 0.005 | 1597.28 (384.98~3956.68) | 0.790 | 659.44 (272.77~2489.36) | 0.725 | | Mutant (7) | 1084.28 (459.27~2184.22) | 1579.45 (501.62~3304.27) | 668.81 (365.36~1149.48) | | NRAS status | | | | | | | | Wild-type (357) | 667.47 (135.30~1532.54) | 0.356 | 1440.21 (364.62~3183.51) | <0.001 | 680.69 (304.00~2568.04) | <0.001 | | Mutant (95) | 683.78 (240.27~1524.89) | 2273.43 (862.43~7465.98) | 572.90 (144.64~1820.63) | | HRAS status | | | | | | | | Wild-type (447) | 669.60 (143.99~1519.00) | 0.792 | 1597.28 (413.96~3950.88) | 0.339 | 658.60 (272.92~2258.13) | 0.030 | | Mutant (5) | 734.55 (97.39~756.41) | 1120.72 (366.42~2219.04) | 2147.36 (276.85~3769.50) | | BRAF status | | | | | | | | Wild-type (270) | 675.86 (139.36~1644.12) | 0.753 | 1665.42 (376.97~4491.40) | 0.015 | 694.15 (258.75~2615.07) | 0.100 | | Mutant (182) | 670.57 (135.98~1482.67) | 1517.62 (392.64~3439.89) | 628.72 (277.64~2247.95) |
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