Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017, Article ID 5356760, 12 pages
https://doi.org/10.1155/2017/5356760
Research Article

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Inflammatory Bowel Disease in Mice

1Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, China
2Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212018, China

Correspondence should be addressed to Xu Zhang; nc.ude.sju@gnahzux and Wenrong Xu; nc.ude.sju@slci

Received 13 January 2017; Revised 6 March 2017; Accepted 14 March 2017; Published 15 May 2017

Academic Editor: Martin Bornhäuser

Copyright © 2017 Fei Mao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. Ahmad, K. M. Muneer, I. A. Tamimi, M. E. Chang, M. O. Ata, and N. Yusuf, “Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome,” Toxicology and Applied Pharmacology, vol. 270, no. 1, pp. 70–76, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Owczarek, T. Rodacki, R. Domagała-Rodacka, D. Cibor, and T. Mach, “Diet and nutritional factors in inflammatory bowel diseases,” World Journal of Gastroenterology, vol. 22, no. 3, pp. 895–905, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Andrews, M. H. McLean, and S. K. Durum, “Interleukin-27 as a novel therapy for inflammatory bowel disease: a critical review of the literature,” Inflammatory Bowel Diseases, vol. 22, no. 9, pp. 2255–2264, 2016. View at Publisher · View at Google Scholar · View at Scopus
  4. M. D. Kappelman, S. L. Rifas-Shiman, C. Q. Porter et al., “Direct health care costs of Crohn's disease and ulcerative colitis in US children and adults,” Gastroenterology, vol. 135, no. 6, pp. 1907–1913, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. J. K. Dyson and M. D. Rutter, “Colorectal cancer in inflammatory bowel disease: what is the real magnitude of the risk?” World Journal of Gastroenterology, vol. 18, no. 29, pp. 3839–3848, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. S. H. Itzkowitz and X. Yio, “Inflammation and cancer, IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation,” The American Journal of Physiology: Gastrointestinal and Liver Physiology, vol. 287, no. 1, pp. G7–G17, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Breynaert, S. Vermeire, P. Rutgeerts, and G. Van Assche, “Dysplasia and colorectal cancer in inflammatory bowel disease: a result of inflammation or an intrinsic risk?” Acta Gastroenterol Belg, vol. 71, no. 4, pp. 367–372, 2008. View at Google Scholar
  8. J. A. Uranga, V. López-Miranda, F. Lombó, and R. Abalo, “Food, nutrients and nutraceuticals affecting the course of inflammatory bowel disease,” Pharmacological Reports, vol. 68, no. 4, pp. 816–826, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Okamoto and M. Watanabe, “Investigating cell therapy for inflammatory bowel disease,” Expert Opinion on Biological Therapy, vol. 16, no. 8, pp. 1015–1023, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Bieback and P. Netsch, “Isolation, culture, and characterization of human umbilical cord blood-derived mesenchymal stromal cells,” Methods in Molecular Biology, vol. 1614, pp. 245–258, 2016. View at Publisher · View at Google Scholar
  11. M. F. Pittenger, A. M. Mackay, S. C. Beck et al., “Multi-lineage potential of adult human mesenchymal stem cells,” Science, vol. 284, pp. 143–147, 1999. View at Publisher · View at Google Scholar
  12. R. J. Deans and A. B. Moseley, “Mesenchymal stem cells: biology and potential clinical uses,” Experimental Hematology, vol. 28, no. 8, pp. 875–884, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. A. R. Williams and J. M. Hare, “Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease,” Circulation Research, vol. 109, no. 8, pp. 923–940, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Polchert, J. Sobinsky, G. W. Douglas et al., “IFN-γ activation of mesenchymal stem cells for treatment and prevention of graft versus host disease,” European Journal of Immunology, vol. 38, no. 6, pp. 1745–1755, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Krampera, L. Cosmi, R. Angeli et al., “Role for interferon-γ in the immunomodulatory activity of human bone marrow mesenchymal stem cells,” Stem Cells, vol. 24, no. 2, pp. 386–398, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Mao, W.-R. Xu, H. Qian et al., “Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis,” Inflammation Research, vol. 59, no. 3, pp. 219–225, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. H. He, Z.-H. Zhao, F.-S. Han, X.-H. Liu, R. Wang, and Y.-J. Zeng, “Overexpression of protein kinase C ε improves retention and survival of transplanted mesenchymal stem cells in rat acute myocardial infarction,” Cell Death and Disease, vol. 7, Article ID e2056, 2016. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Qian, H. Yang, W. Xu et al., “Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial-like cells,” International Journal of Molecular Medicine, vol. 22, no. 3, pp. 325–332, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Fu, H. Zhang, Y. Zhuang et al., “The role of N-acetyltransferase 8 in mesenchymal stem cell-based therapy for liver ischemia/reperfusion injury in rats,” PLoS ONE, vol. 9, no. 7, Article ID e103355, 2014. View at Publisher · View at Google Scholar
  20. J. S. Schorey and S. Bhatnagar, “Exosome function: from tumor immunology to pathogen biology,” Traffic, vol. 9, no. 6, pp. 871–881, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Li, Y. Yan, B. Wang et al., “Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis,” Stem Cells and Development, vol. 22, no. 6, pp. 845–854, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Zhou, H. Xu, W. Xu et al., “Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro,” Stem Cell Research & Therapy, vol. 4, no. 2, article 34, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Gatti, S. Bruno, M. C. Deregibus et al., “Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury,” Nephrology Dialysis Transplantation, vol. 26, no. 5, pp. 1474–1483, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Bruno, C. Grange, F. Collino et al., “Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury,” PLoS ONE, vol. 7, no. 3, Article ID e33115, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. R. C. Lai, F. Arslan, M. M. Lee et al., “Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury,” Stem Cell Research, vol. 4, no. 3, pp. 214–222, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. C. Qiao, W. Xu, W. Zhu et al., “Human mesenchymal stem cells isolated from the umbilical cord,” Cell Biology International, vol. 32, no. 1, pp. 8–15, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. B. Zhang, L. Shen, H. Shi et al., “Exosomes from human umbilical cord mesenchymal stem cells: identification, purification, and biological characteristics,” Stem Cells International, vol. 2016, Article ID 1929536, 11 pages, 2016. View at Publisher · View at Google Scholar
  28. Y. T. Chang, “Long-term cultivation of mouse peritoneal macrophages,” Journal of the National Cancer Institute, vol. 32, no. 1, pp. 19–35, 1964. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Zhou, H. Xu, W. Xu et al., “Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro,” Stem Cell Research & Therapy, vol. 4, Article ID 34, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Zhao, X. Sun, W. Cao et al., “Exosomes derived from human umbilical cord mesenchymal stem cells relieve acute myocardial ischemic injury,” Stem Cells International, vol. 2015, Article ID 761643, 12 pages, 2015. View at Publisher · View at Google Scholar
  31. L. Sun, R. Xu, X. Sun et al., “Safety evaluation of exosomes derived from human umbilical cord mesenchymal stromal cell,” Cytotherapy, vol. 18, pp. 413–422, 2016. View at Publisher · View at Google Scholar
  32. I. Shureiqi, Y. Wu, D. Chen, X. L. Yang, B. Guan, J. S. Morris et al., “The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis,” Cancer Research, vol. 65, no. 24, pp. 11486–11492, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Nemoto, T. Kanai, M. Takahara et al., “Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells,” Gut, vol. 62, no. 8, pp. 1142–1152, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Watanabe, Y. Arimura, K. Nagaishi et al., “Conditioned mesenchymal stem cells produce pleiotropic gut trophic factors,” Journal of Gastroenterology, vol. 49, no. 2, pp. 270–282, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Nagaishi, Y. Arimura, and M. Fujimiya, “Stem cell therapy for inflammatory bowel disease,” Journal of Gastroenterology, vol. 50, no. 3, pp. 280–286, 2015. View at Publisher · View at Google Scholar
  36. E. Pap, É. Pállinger, M. Pásztói, and A. Falus, “Highlights of a new type of intercellular communication: microvesicle-based information transfer,” Inflammation Research, vol. 58, no. 1, pp. 1–8, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. W. F. Doe and B. Dorsman, “Chronic inflammatory bowel disease--increased plasminogen activator secretion by mononuclear phagocytes,” Clin Exp Immunol, vol. 48, no. 1, pp. 256–260, 1982. View at Google Scholar
  38. M. Genua, V. Ingangi, P. Fonteyne et al., “Treatment with a urokinase receptor-derived cyclized peptide improves experimental colitis by preventing monocyte recruitment and macrophage polarization,” Inflammatory Bowel Diseases, vol. 22, no. 10, pp. 2390–2401, 2016. View at Publisher · View at Google Scholar
  39. B. Shen, J. Liu, F. Zhang et al., “CCR2 positive exosome released by mesenchymal stem cells suppresses macrophage functions and alleviates ischemia/reperfusion-induced renal injury,” Stem Cells International, vol. 2016, Article ID 1240301, 9 pages, 2016. View at Publisher · View at Google Scholar
  40. X. Li, L. Liu, J. Yang et al., “Exosome derived from human umbilical cord mesenchymal stem cell mediates mir-181c attenuating burn-induced excessive inflammation,” EBioMedicine, vol. 8, pp. 72–82, 2016. View at Publisher · View at Google Scholar · View at Scopus
  41. C. M. Capitini, A. A. Chisti, and C. L. MacKall, “Modulating T-cell homeostasis with IL-7: preclinical and clinical studies,” Journal of Internal Medicine, vol. 266, no. 2, pp. 141–153, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. T. Ji, C. Xu, L. Sun et al., “Aryl hydrocarbon receptor activation down-regulates IL-7 and reduces inflammation in a mouse model of DSS-induced colitis,” Digestive Diseases and Sciences, vol. 60, no. 7, pp. 1958–1966, 2015. View at Publisher · View at Google Scholar · View at Scopus
  43. G. Kleiner, V. Zanin, L. Monasta et al., “Pediatric patients with inflammatory bowel disease exhibit increased serum levels of proinflammatory cytokines and chemokines, but decreased circulating levels of macrophage inhibitory protein-1β, interleukin-2 and interleukin-17,” Experimental and Therapeutic Medicine, vol. 9, no. 6, pp. 2047–2052, 2015. View at Publisher · View at Google Scholar · View at Scopus
  44. O. Y. Korolkova, J. N. Myers, S. T. Pellom, L. Wang, and A. E. M’Koma, “Characterization of serum cytokine profile in predominantly colonic inflammatory bowel disease to delineate ulcerative and crohn's colitides,” Clinical Medicine Insights Gastroenterol, vol. 8, pp. 29–44, 2015. View at Publisher · View at Google Scholar · View at Scopus
  45. W.-Y. Wong, M. M.-L. Lee, B. D. Chan et al., “Proteomic profiling of dextran sulfate sodium induced acute ulcerative colitis mice serum exosomes and their immunomodulatory impact on macrophages,” Proteomics, vol. 16, no. 7, pp. 1131–1145, 2016. View at Publisher · View at Google Scholar · View at Scopus
  46. F. Collino, M. C. Deregibus, S. Bruno et al., “Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs,” PLoS ONE, vol. 5, Article ID e11803, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. B. Zhang, M. Wang, A. Gong et al., “HucMSC-exosome mediated-wnt4 signaling is required for cutaneous wound healing,” Stem Cells, vol. 33, pp. 2158–2168, 2015. View at Publisher · View at Google Scholar
  48. Y. Yan, W. Jiang, Y. Tan et al., “hucMSC exosome-derived gpx1 is required for the recovery of hepatic oxidant injury,” Mol Ther, vol. 25, pp. 465–479, 2017. View at Publisher · View at Google Scholar
  49. R. C. Lai, S. S. Tan, B. J. Teh et al., “Proteolytic potential of the MSC exosome proteome: implications for an exosome-mediated delivery of therapeutic proteasome,” International Journal of Proteomics, vol. 2012, Article ID 971907, 14 pages, 2012. View at Publisher · View at Google Scholar
  50. H.-S. Kim, D.-Y. Choi, S. J. Yun et al., “Proteomic analysis of microvesicles derived from human mesenchymal stem cells,” Journal of Proteome Research, vol. 11, no. 2, pp. 839–849, 2012. View at Publisher · View at Google Scholar · View at Scopus