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BioMed Research International
Volume 2017, Article ID 5358615, 11 pages
Research Article

The Clinical Values of Serum Markers in the Early Prediction of Hepatocellular Carcinoma

1Center for Clinical Laboratory, 302 Military Hospital, Beijing, China
2Graduate Student Team, Medical University of PLA, Beijing, China

Correspondence should be addressed to Yuanli Mao; moc.nuyila@618087ipip

Received 9 December 2016; Accepted 9 March 2017; Published 30 April 2017

Academic Editor: Tzi Bun Ng

Copyright © 2017 Bo Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The early prediction values of diagnostic markers for hepatocellular carcinoma (HCC) are still unclear at present. This study evaluated the prediction value of ten serum markers in HCC. A total of 109 cases of hepatic cirrhosis patients were followed up for 36 months and the relationship between the lifetime risk of developing HCC and levels of serum markers was analyzed. 31.2 (34/109) percent of hepatic cirrhosis patients developed HCC during the study’s timeframe. Higher alpha-fetoprotein (AFP), alpha-fetoprotein-L3 (AFP-L3), alanine aminotransferase (ALT), and AFP-L3/AFP ratio levels are potential risk factors for malignization in hepatic cirrhosis patients (, 2.92, 2.72, and 2.34); serum Golgi protein 73 (GP73) level of hepatic cirrhosis patients decreased significantly after developing HCC (; ). The detection of ALT, AFP, AFP-L3, and GP73 has a certain guiding significance to predict the risk of HCC in hepatic cirrhosis patients.