The Clinical Values of Serum Markers in the Early Prediction of Hepatocellular Carcinoma

Table 4

The predictive value of all markers and combination of 3 markers for HCC in cirrhotic patients.

Markers	Area under ROC curve	Standard error	value	95% confidence interval	Cut-off	Sensitivity	Specificity
ALB (g/l)	0.537	0.059	0.534	0.423–0.652	28.5	0.765	0.373
TBIL (μmol/L)	0.537	0.058	0.537	0.423–0.651	15.15	0.912	0.293
ALT (U/L)	0.693	0.056	0.001	0.582–0.803	44.5	0.676	0.680
PLT (10^9/L)	0.559	0.057	0.327	0.447–0.670	45.5	0.882	0.720
PT(s) (s)	0.426	0.058	0.216	0.311–0.540	21.5	0.029	1.000
PT(a) (%)	0.591	0.058	0.128	0.477–0.705	75	0.529	0.693
AFP (ng/mL)	0.736	0.052	0.000	0.634–0.839	10.28	0.676	0.693
GP73 (ng/mL)	0.539	0.061	0.513	0.419–0.659	221.85	0.471	0.693
AFP-L3 (ng/mL)	0.744	0.052	0.000	0.642–0.846	0.514	0.676	0.693
L3/AFP ratio	0.606	0.065	0.077	0.478–0.734	0.052	0.500	0.760
ALT + AFP + AFP-L3	0.770	0.050	0.000	0.672–0.868	0.23	0.824	0.667
ALT + AFP	0.780	0.049	0.000	0.683–0.877	0.24	0.824	0.693
ALT + AFP-L3	0.773	0.050	0.000	0.676–0.871	0.23	0.824	0.680
AFP + AFP-L3	0.740	0.052	0.000	0.638–0.842	0.23	0.676	0.693