The Distribution of Phosphatidylcholine Species in Superficial-Type Pharyngeal Carcinoma

Figure 3

Ion images of signals in the subepithelial invasive region that were increased in all STPSCC cases and molecular identification. (a) Ion images of signals in the subepithelial invasive region that were increased in all STPSCC cases. The white dashed lines indicate ROIs of the superficial (A) and subepithelial invasive (B) regions in STPSCC (scale bar: 1.0 mm). (b) (A) Results of MS/MS analysis of 820.5. The product ions from 820.5 as a precursor ion were obtained in the subepithelial invasive region of STPSCC. This biomolecule was identified as [PC (16:0/20:4) + K]⁺. (B) The precursor peak at 846.5 was identified in the same manner as [PC (18:1/20:4) + K]⁺. (C) The precursor peak at 848.5 was identified as [PC (18:0/20:4) + K]⁺. All identified molecules that had a higher signal intensity in the subepithelial invasive region of STPSCC contained an arachidonic acid (20:4).

(a)

(b)