Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2017 (2017), Article ID 5387948, 7 pages
https://doi.org/10.1155/2017/5387948
Research Article

Correlation between Pathological Characteristics and Young’s Modulus Value of Spastic Gastrocnemius in a Spinal Cord Injury Rat Model

1Department of Rehabilitation, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
2Department of Ultrasound, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
3Institute of Medical Information, School of Biomedical Engineering, Southern Medical University, Guangzhou, China
4Department of Gastroenterology Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

Correspondence should be addressed to Wei-ping Guo; moc.621@658gnipwg and Zu-lin Dou; moc.361@luzuod

Received 30 August 2017; Accepted 3 December 2017; Published 27 December 2017

Academic Editor: Yongjin Zhou

Copyright © 2017 Li Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The goal of the present study were (1) to investigate the pathological characteristics of gastrocnemius muscle (GM) and quantitatively assess GM tissue stiffness in rat models with spinal cord injury (SCI) and (2) to explore the correlation between pathological characteristics changes and Young’s modulus value of GM. 24 Sprague Dawley male rats were allocated into normal control groups and SCI model subgroups, respectively. GM stiffness was assessed with shear wave sonoelastography technology. All GMs were further analyzed by pathological examinations. GM weights were decreased, the ratio of type I fibers was decreased, and the ratio of type II fibers was increased in the GM in the model group. MyHC-I was decreased, while MyHC-II was increased according to the electrophoretic analysis in model subgroups. The elastic modulus value of GM was increased in the model group. A significant negative correlation was found between Young’s modulus value of GM and the ratio of type I fibers of GM in model subgroup. Our studies showed that the stiffness of GM is correlated with pathological characteristics during the initial stages of SCI in rats. We also identified shear wave sonoelastography technology as a useful tool to assess GM stiffness in SCI rat models.