Comparison of DNA Methylation in Schwann Cells before and after Peripheral Nerve Injury in Rats

Table 5

Significant KEGG signaling pathways of methylated genes.

Pathway	Gene number	value	Partial related methylated genes
Calcium signaling pathway	136	0.01	Phka2, Adcy7, Hrh2, Drd1, Grm1, Vdac1, Grm5, Pde1b, Tnnc2, Nos1, Camk4
cAMP signaling pathway	143	0.02	Vav3, Drd2, Adcy10, Rhoa, Sox9, Mc2r, Gli3, Cngb3, Rras, Adcy1, Rac1
cGMP-PKG signaling pathway	126	0.02	Adcy7, Irs1, Npr2, Mylk, Rhoa, Adrb1, Ins2, Adcy5, Gna12, Itpr3, Prkg1
Wnt signaling pathway	105	0.03	Fzd5, Nlk, Smad4, Chd8, Plcb1, Sfrp4, Sost, Mapk8, Gsk3b, Lrp5, Rac1
Rap1 signaling pathway	150	0.03	Kit, Magi1, Krit1, Plce1, Pgf, Csf1, Tln1, Cdh1, Skap1, Fgf8, Rac1, Actg1
ERK signaling pathway	62	0.04	Mtor, Nck1, Erbb3, Egf, Araf, Pak7, Shc3, Plcg2, Ptk2, Tgfa, Nrg1, Kras
PI3-Akt signaling pathway	209	0.04	Itga4, Ccne1, Gng7, Cdc37, Tlr2, Ccnd3, Gngt1, Hgf, Syk, Fgf1, Tnr, Tnc
Hippo/YAP signaling pathway	104	0.04	Fzd5, Mpp5, Crb2, Gsk3b, Tead1, Ccnd1, Actb, Smad3, Dlg1, Fzd4, Bmp7
MAPK signaling pathway	172	0.04	Atf2, Cd14, Rras2, Ntf3, Rap1b, Grb2, Dusp1, Stk4, Mapk3, Jun, Nf1

KEGG: Kyoto Encyclopedia of Genes and Genomes.