Review Article
Association between ADAM12 Single-Nucleotide Polymorphisms and Knee Osteoarthritis: A Meta-Analysis
Table 1
Allele and genotypes distribution of ADAM12 polymorphisms in cases and controls.
| Study | Country | Ethnicity | Study design | Case-control | Case | Control | HWE |
| rs3740199 | | | | | CC | CG | GG | CC | CG | GG | | Kerna et al., 2009 | Estonia | Caucasian | Case-control | 66/123 | 81 | 66 | 16 | 106 | 89 | 20 | 0.37 | Lou et al., 2014 | China | Asian | Case-control | 152/179 | 32 | 78 | 42 | 42 | 93 | 44 | 0.60 | Poonpet et al., 2016 | Thailand | Asian | Case-control | 200/200 | 56 | 102 | 42 | 46 | 100 | 54 | 0.98 | Rodriguez-Lopez et al., 2009 | Spain | Caucasian | Case-control | 1602/2370 | NA | NA | NA | NA | NA | NA | >0.05 | Shin et al., 2012 | Korea | Asian | Case-control | 725/1737 | 147 | 364 | 214 | 350 | 863 | 524 | 0.88 | Valdes et al., 2006 | UK | Caucasian | Case-control | 603/596 | NA | NA | NA | NA | NA | NA | >0.10 | Wang et al., 2015 | China | Asian | Case-control | 164/200 | 36 | 84 | 44 | 47 | 102 | 51 | 0.77 | rs1871054 | | | | | CC | TC | TT | CC | TC | TT | | Kerna etal., 2009 | Estonia | Caucasian | Case-control | 66/123 | 42 | 79 | 42 | 50 | 111 | 54 | 0.63 | Lou et al., 2014 | China | Asian | Case-control | 152/179 | 69 | 57 | 26 | 44 | 88 | 47 | 0.83 | Valdes et al., 2006 | UK | Caucasian | Case-control | 603/596 | NA | NA | NA | NA | NA | NA | >0.10 | Wang et al., 2015 | China | Asian | Case-control | 164/200 | 76 | 59 | 29 | 49 | 99 | 52 | 0.89 | rs1044122 | | | | | CC | TC | TT | CC | TC | TT | | Lou et al., 2014 | China | Asian | Case-control | 152/179 | 24 | 81 | 47 | 31 | 92 | 56 | 0.52 | Valdes et al., 2006 | UK | Caucasian | Case-control | 603/596 | NA | NA | NA | NA | NA | NA | >0.10 | Wang et al., 2015 | China | Asian | Case-control | 164/200 | 25 | 88 | 51 | 37 | 101 | 62 | 0.71 | rs1278279 | | | | | AA | AG | GG | AA | AG | GG | | Lou et al., 2014 | China | Asian | Case-control | 152/179 | 9 | 59 | 84 | 13 | 60 | 106 | 0.32 | Valdes et al., 2006 | UK | Caucasian | Case-control | 603/596 | NA | NA | NA | NA | NA | NA | >0.10 | Wang et al., 2015 | China | Asian | Case-control | 164/200 | 10 | 62 | 92 | 15 | 64 | 121 | 0.12 |
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NA: not available; HWE: Hardy-Weinberg equilibrium.
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