Association between ADAM12 Single-Nucleotide Polymorphisms and Knee Osteoarthritis: A Meta-Analysis

Table 1

Allele and genotypes distribution of ADAM12 polymorphisms in cases and controls.

Study	Country	Ethnicity	Study design	Case-control	Case			Control			HWE
rs3740199					CC	CG	GG	CC	CG	GG
Kerna et al., 2009	Estonia	Caucasian	Case-control	66/123	81	66	16	106	89	20	0.37
Lou et al., 2014	China	Asian	Case-control	152/179	32	78	42	42	93	44	0.60
Poonpet et al., 2016	Thailand	Asian	Case-control	200/200	56	102	42	46	100	54	0.98
Rodriguez-Lopez et al., 2009	Spain	Caucasian	Case-control	1602/2370	NA	NA	NA	NA	NA	NA	>0.05
Shin et al., 2012	Korea	Asian	Case-control	725/1737	147	364	214	350	863	524	0.88
Valdes et al., 2006	UK	Caucasian	Case-control	603/596	NA	NA	NA	NA	NA	NA	>0.10
Wang et al., 2015	China	Asian	Case-control	164/200	36	84	44	47	102	51	0.77
rs1871054					CC	TC	TT	CC	TC	TT
Kerna etal., 2009	Estonia	Caucasian	Case-control	66/123	42	79	42	50	111	54	0.63
Lou et al., 2014	China	Asian	Case-control	152/179	69	57	26	44	88	47	0.83
Valdes et al., 2006	UK	Caucasian	Case-control	603/596	NA	NA	NA	NA	NA	NA	>0.10
Wang et al., 2015	China	Asian	Case-control	164/200	76	59	29	49	99	52	0.89
rs1044122					CC	TC	TT	CC	TC	TT
Lou et al., 2014	China	Asian	Case-control	152/179	24	81	47	31	92	56	0.52
Valdes et al., 2006	UK	Caucasian	Case-control	603/596	NA	NA	NA	NA	NA	NA	>0.10
Wang et al., 2015	China	Asian	Case-control	164/200	25	88	51	37	101	62	0.71
rs1278279					AA	AG	GG	AA	AG	GG
Lou et al., 2014	China	Asian	Case-control	152/179	9	59	84	13	60	106	0.32
Valdes et al., 2006	UK	Caucasian	Case-control	603/596	NA	NA	NA	NA	NA	NA	>0.10
Wang et al., 2015	China	Asian	Case-control	164/200	10	62	92	15	64	121	0.12

NA: not available; HWE: Hardy-Weinberg equilibrium.