BioMed Research International

Research Article

Susceptibility of In Vitro Melanoma Skin Cancer to Photoactivated Hypericin versus Aluminium(III) Phthalocyanine Chloride Tetrasulphonate

Table 3

LDH membrane integrity assay to evaluate PDT effect of Hyp and AlPcS4Cl.
 Cells + no PS, no LICells +
2,5 µM PS		Cells +
5 J/cm2		Cells +
2,5 µM PS + 1 J/cm2		Cells +
2,5 µM PS
+ 2.5 J/cm2		Cells +
2,5 µM PS + 5 J/cm2		Cells +
2,5 µM PS
+ 10 J/cm2
AlPcS4Cl
1 hr0.460
± 0.039		0.470
± 0.026		0.386
± 0.026		0.485
± 0.031		0.494
± 0.024		0.492
± 0.029		0.507
± 0.031
4 hrs0.476
± 0.016		0.489
± 0.014		0.445
± 0.026		0.500
± 0.014		0.525
± 0.016		0.545
± 0.020		0.534
± 0.028
24 hrs0.407
± 0.018		0.448
± 0.014		0.360
± 0.017		0.412
± 0.024		0.515
± 0.035		0.524
± 0.036		0.535
± 0.036
Hyp
1 hrs0.453
± 0.017		0.467
± 0.017		0.428
± 0.020		0.475
± 0.017		0.482
± 0.016		0.495
± 0.018		0.562
± 0.045
4 hrs0.431
± 0.012		0.445
± 0.011		0.403
± 0.018		0.461
± 0.013		0.471
± 0.013		0.527
± 0.033		0.539
± 0.035
24 hrs0.450
± 0.006		0.480
± 0.009		0.438
± 0.009		0.496
± 0.010		0.500
± 0.011		0.527
± 0.010		0.566
± 0.030
; LDH: Lactate Dehydrogenase; LI: laser irradiation; PS: photosensitizer; ; ; ±SE.