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BioMed Research International
Volume 2017, Article ID 5421416, 5 pages
Research Article

Relationship between Interferon Beta-1A Administration and Intracranial Vascular Tone Regulation in Patients with Relapsing-Remitting Multiple Sclerosis: A Pilot Study

1IRCCS Centro Neurolesi “Bonino Pulejo”, Via P.le Palermo S.S. 113, 98124 Messina, Italy
2Department of Human Pathology, University Hospital of Messina, Via Consolare Valeria, Messina, Italy
3Department of Clinical and Experimental Medicine, University Hospital of Messina, Via Consolare Valeria, Messina, Italy

Correspondence should be addressed to Vincenzo Dattola; moc.liamg@alottad.oznecniv

Received 30 May 2017; Revised 27 July 2017; Accepted 14 August 2017; Published 13 September 2017

Academic Editor: Luca Prosperini

Copyright © 2017 Vincenzo Dattola et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Interferon beta (IFN-β) therapy is one of the most commonly prescribed immunomodulatory therapies in relapsing-remitting multiple sclerosis (RRMS). A reversible cerebral vasoconstriction syndrome (RCVS), associated with IFN-β use, has been recently described. For this reason, we tested the effect of once a week intramuscular administration of IFN-β-1A on the function of cerebral vessels in a cohort of RRMS patients. Using transcranial Doppler (TCD) ultrasound, we measured the mean blood flow velocity (MFV) in intracranial vessels 10 h after IFN-β administration. Measurements showed a significant increase in MFV compared to the baseline values in some vessels.