High Prevalence of Leptotrichia amnionii, Atopobium vaginae, Sneathia sanguinegens, and Factor 1 Microbes and Association of Spontaneous Abortion among Korean Women

Table 4

Rank correlations between epidemiological factors and relative abundances of microbial species.

Epidemiological factors	Bacteria	Coefficient	value
Age group	Aerococcus christensenii	0.1343592	0.027
Age group	Peptoniphilus indolicus	0.1209233	0.008
Age group	Pseudomonas trivialis	0.0916399	0.038
Age group	Streptococcus agalactiae	0.0877354	0.021
Age group	Peptostreptococcus anaerobius	0.0625861	0.046
Age group	Lactobacillus psittaci	−0.107028	0.045
Age group	Lactobacillus vaginalis	−0.1264355	0.011
Alcohol-drinking status	Peptostreptococcus anaerobius	−0.1295681	0.033
Alcohol-drinking status	Peptoniphilus indolicus	−0.1548173	0.042
Duration of alcohol drinking	Ureaplasma parvum	0.1506007	0.034
Duration of alcohol drinking	Peptostreptococcus anaerobius	−0.0775172	0.037
Frequency of alcohol drinking	Peptostreptococcus anaerobius	−0.0852376	0.024
Frequency of alcohol drinking	Aerococcus christensenii	−0.141315	0.023
BMI group	Streptococcus agalactiae	0.0861567	0.041
Breast feeding status	Microbacterium hydrocarbonoxydan	0.0943396	0.001
Breast feeding status	Escherichia fergusonii	0.0566038	0.013
Breast feeding status	Lactobacillus acidophilus	0.0471698	0.023
Number of breast feedings	Lactobacillus acidophilus	0.064167	0.034
Number of children	Streptococcus anginosus	0.115846	0.029
Education group	Lactobacillus fornicalis	0.1377228	0.032
Education group	Lactobacillus jensenii	0.1368603	0.007
Education group	Lactobacillus vaginalis	0.1236343	0.031
Education group	Lactobacillus acidophilus	−0.0715929	0.028
First parity age	Lactobacillus acidophilus	−0.0587645	0.031
Heavy physical days	AY995258_s	−0.0465116	0.013
Heavy physical days	Pseudomonas cedrina	−0.0775194	0.001
Heavy physical days	Lactobacillus crispatus	−0.250918	0.025
Family income level group	Prevotella bivia	0.1919973	0.002
Family income level group	Lactobacillus crispatus	0.169805	0.027
Family income level group	Lactobacillus fornicalis	0.1585407	0.014
Family income level group	Lactobacillus jensenii	0.1482851	0.004
Family income level group	Lactobacillus psittaci	0.1410558	0.019
Family income level group	Sneathia sanguinegens	−0.1516476	0.006
Induced abortion	Leptotrichia amnionii	0.1887626	0.006
Induced abortion	AY958940 s	0.1171086	0.016
Number of induced abortions	Leptotrichia amnionii	0.1085734	0.041
Medium physical days	Pseudomonas trivialis	0.1102151	0.039
Menarche age	AY995258_s	−0.0666989	0.012
Menstrual cycle	Pseudomonas trivialis	0.1332942	0.013
Menstrual cycle	Lactobacillus fornicalis	−0.1884909	0.01
Menstrual regulation	AY959069_s	−0.1232877	0.002
Menstrual regulation	AY959023_s	−0.1438356	0.03
Menstrual regulation	Leptotrichia amnionii	−0.1637609	0.024
Mensday regulation	Streptococcus agalactiae	−0.0625	0.023
Mensday regulation	Pseudomonas trivialis	−0.1125	0.002
Mensday regulation	AY959069_s	−0.1125	0.002
Mensday regulation	Streptococcus pseudopneumoniae	−0.1125	0.002
Mensday regulation	Ureaplasma urealyticum	−0.1375	0
Mensday regulation	Prevotella amnii	−0.15	0
Mensday regulation	_P003395_s	−0.1625	0
Mensday regulation	Lactobacillus vaginalis	−0.2163462	0.03
Mensday regulation	Aerococcus christensenii	−0.2269231	0.021
Mensday	_P003395_s	−0.1732194	0.009
Mensday	Prevotella timonensis	−0.2017094	0.019
Oral contraceptive use	Staphylococcus epidermidis	−0.1	0.04
Oral contraceptive use	Streptococcus anginosus	−0.1532258	0
Sitting time	Escherichia fergusonii	0.0714913	0.023
Sitting time	Microbacterium hydrocarbonoxydan	−0.0790167	0.04
Sitting time	Pseudomonas trivialis	−0.1163928	0.009
Smoking	Escherichia fergusonii	−0.0451128	0.013
Smoking	Ureaplasma urealyticum	−0.1654135	0
Smoking	Aerococcus christensenii	−0.2230576	0.035
Spontaneous abortion	Atopobium vaginae	0.3357488	0.026
Spontaneous abortion	Sneathia sanguinegens	0.3115942	0.009
Spontaneous abortion	AY959109_s	0.3007246	0.015
Spontaneous abortion	Gardnerella vaginalis	0.2862319	0.045
Spontaneous abortion	Leptotrichia amnionii	0.2657005	0.024
Spontaneous abortion	AY958940_s	0.2258454	0.021
Spontaneous abortion	Streptococcus pseudopneumoniae	−0.1594203	0.043
Spontaneous abortion	Lactobacillus fornicalis	−0.2222222	0.049
Spontaneous abortion	Ureaplasma urealyticum	−0.25	0.001
Number of spontaneous abortions	Atopobium vaginae	0.2729167	0.045
Number of spontaneous abortions	AY959109_s	0.2552083	0.017
Number of spontaneous abortions	Sneathia sanguinegens	0.2416667	0.026
Number of spontaneous abortions	Leptotrichia amnionii	0.2125	0.045
Number of spontaneous abortions	AY958940_s	0.178125	0.042
Number of spontaneous abortions	Staphylococcus epidermidis	−0.1239583	0.042
Number of spontaneous abortions	Lactobacillus fornicalis	−0.2	0.045
Number of spontaneous abortions	Ureaplasma urealyticum	−0.215625	0.001
Walking hours per day	Lactobacillus iners	0.1760537	0.016
Walking hours per day	Pseudomonas trivialis	−0.1173691	0.009

Forty-five (45) species filtered for the 0.1%-or-over rate among total species identified using pyrosequencing. Continuous variables (age, BMI, first parity age, walking day for 10 min or longer per week, menstrual day, menstrual cycle, and duration of oral contraceptive use) and categorical variables (marital status, education level, family income level, smoking frequency, duration of smoking, alcohol drinking, alcohol-drinking frequency, spontaneous abortion, number of spontaneous abortions, and number of children) of 27 factors were used for the analysis. Somers’ rank correlation coefficients were measured and presented. was considered to be significant. − means negative correlation.